A Modified Synthetic Approach to Optically Pure Benzoxazepines from Amino Acid Precursors Using Intramolecular Buchwald-Hartwig C-O Bond-Formation Reaction

Autor:	Partha Chattopadhyay, Debleena Bhattacharya, Sandip K. Hota, Ashok Behera
Rok vydání:	2011
Předmět:	chemistry.chemical_compound Intramolecular reaction Chemistry Ligand Intramolecular force Aryl Organic Chemistry Enantiomeric excess Ring (chemistry) Chemical synthesis Combinatorial chemistry Catalysis
Zdroj:	Synthesis. 2011:585-592
ISSN:	1437-210X 0039-7881
Popis:	Palladium-catalyzed intramolecular aryl etherification reaction using bulky binaphthylphosphane ligand is shown to be a convenient method for the synthesis of seven-membered heterocy- cles. Application of this methodology to a naturally occurring pro- teinogenic L-amino acid has led to the synthesis of optically active benzoxazepine ring systems of versatile biological importance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1ac87026499fe187b8e1aca061a78de7 https://doi.org/10.1055/s-0030-1258406 Zobrazit plný text záznamu