Effect of oleamide on water and sodium ion transport in osmoregulatory organs of vertebrates
| Autor: | A. E. Bogolepova, Yu. V. Natochin, E. I. Shakhmatova, Michael V. Dubina |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Oleamide Physiology Chemistry Reabsorption medicine.medical_treatment Intraperitoneal injection Diuresis Sodium ion transport Biochemistry Rana Excretion chemistry.chemical_compound Endocrinology Internal medicine medicine Ecology Evolution Behavior and Systematics Ion transporter |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 51:499-504 |
| ISSN: | 1608-3202 0022-0930 |
| DOI: | 10.1134/s0022093015060071 |
| Popis: | In the frog Rana temporaria L., oleamide solution (10 μmole/L) applied to the isolated basal surface of the skin augmented the short-circuit current (SCC) from 59.8 ± 2.5 to 78.2 ± 1.4 μA/cm2. When applied to the serous membrane of the urinary bladder, oleamide (1 μmole/L) induced more than a 30-fold increase in osmotic water permeability. The addition of argininevasotocin against the background of oleamide further increased SCC across the skin and osmotic water permeability in the bladder. In Wistar rats, intraperitoneal injection of oleamide (0.1 μmole/L per 100 g of body weight) to non-anesthetized animals after water load reduced diuresis by 22% and increased solute-free water reabsorption and urinary sodium excretion by 31% and 55%, respectively, but did not affect urinary potassium excretion. These findings provide evidence of the similarity between the effects of oleamide and nonapeptide neurohypophyseal hormones on water and ion transport in epithelial cells of osmoregulatory organs in vertebrates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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