Cortico-limbic connectivity in MAOA -L carriers is vulnerable to acute tryptophan depletion
| Autor: | Florian D. Zepf, Mikhail Zvyagintsev, Klaus Zerres, Dhana Wolf, Klaus Mathiak, Thomas Eggermann, Krystyna A. Mathiak, Patrick Eisner, Pegah Sarkheil, Albrecht Eisert, Martin Klasen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Serotonergic
Amygdala 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging Prefrontal cortex Radiological and Ultrasound Technology medicine.diagnostic_test Resting state fMRI biology 030227 psychiatry medicine.anatomical_structure nervous system Neurology biology.protein Neurology (clinical) Serotonin Anatomy Monoamine oxidase A Functional magnetic resonance imaging Psychology Insula Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping. 38:1622-1635 |
| ISSN: | 1065-9471 |
| Popis: | INTRODUCTION A gene-environment interaction between expression genotypes of the monoamine oxidase A (MAOA) and adverse childhood experience increases the risk of antisocial behavior. However, the neural underpinnings of this interaction remain uninvestigated. A cortico-limbic circuit involving the prefrontal cortex (PFC) and the amygdala is central to the suppression of aggressive impulses and is modulated by serotonin (5-HT). MAOA genotypes may modulate the vulnerability of this circuit and increase the risk for emotion regulation deficits after specific life events. Acute tryptophan depletion (ATD) challenges 5-HT regulation and may identify vulnerable neuronal circuits, contributing to the gene-environment interaction. METHODS Functional magnetic resonance imaging measured the resting-state state activity in 64 healthy males in a double-blind, placebo-controlled study. Cortical maps of amygdala correlation identified the impact of ATD and its interaction with low- (MAOA-L) and high-expression variants (MAOA-H) of MAOA on cortico-limbic connectivity. RESULTS Across all Regions of Interest (ROIs) exhibiting an ATD effect on cortico-limbic connectivity, MAOA-L carriers were more susceptible to ATD than MAOA-H carriers. In particular, the MAOA-L group exhibited a larger reduction of amygdala connectivity with the right prefrontal cortex and a larger increase of amygdala connectivity with the insula and dorsal PCC. CONCLUSION MAOA-L carriers were more susceptable to a central 5-HT challenge in cortico-limbic networks. Such vulnerability of the cortical serotonergic system may contribute to the emergence of antisocial behavior after systemic challenges, observed as gene-environment interaction. Hum Brain Mapp 38:1622-1635, 2017. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|