Development of Factor VIII Antibody in Haemophilic Monozygotic Twins

Autor: F. Panicucci, P. M. Mannucci, S. Chiara, Janine Seger, J. Y. Muller, J. P. Allain, Zaverio M. Ruggeri, U. Baicchi, F. Mercuriali, D. Frommel
Rok vydání: 2009
Předmět:
Zdroj: Scandinavian Journal of Haematology. 23:64-68
ISSN: 0036-553X
DOI: 10.1111/j.1600-0609.1979.tb02856.x
Popis: The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non-concordance illustrates the influence upon a specific immune response of non-genetic factors since the blood products, administered to each brother-pair, were not at all time identical nor were the regimens of transfusion therapy.
Databáze: OpenAIRE