Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect
| Autor: | W. Drenthen, Folkert J. Meijboom, J.W. Roos-Hesselink, Vincent W. V. Jaddoe, Zahara investigators, Sing-Chien Yap, Barbara J.M. Mulder, P. G. Pieper, Eric A.P. Steegers, Philip Moons, Eric Boersma, Hubert W. Vliegen, A.P.J. van Dijk |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Heart septal defect Pediatrics medicine.medical_specialty Pregnancy Obstetrics business.industry Obstetrics and Gynecology Retrospective cohort study Odds ratio medicine.disease Premature birth medicine Small for gestational age Prospective cohort study business Cohort study |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 117:683-689 |
| ISSN: | 1470-0328 |
| DOI: | 10.1111/j.1471-0528.2010.02512.x |
| Popis: | OBJECTIVE: To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD). DESIGN: A retrospective multicentre study. SETTING: Tertiary centres in the Netherlands and Belgium. METHODS: Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy (n = 147; unrepaired VSD, n = 104; repaired VSD, n = 43) was obtained using medical records and telephone interviews. Data from the Generation R database (prospective cohort study; n = 9667) were used to determine the background risk (controls). Odds ratios and 95% CI were estimated using general estimation equation analysis adjusted for multiple pregnancies per woman, maternal age and parity status. MAIN OUTCOME MEASURES: Adjusted odds ratios (AORs) for developing pregnancy complications in relation to corrective status. RESULTS: Pregnancies in women with an unrepaired VSD were associated with a higher risk of pre-eclampsia (AOR 4.59, 95% CI 2.01-10.5, P < 0.001) compared with controls. No differences were observed when comparing women with repaired VSD and controls. Pregnancies in women with repaired VSD were associated with a higher risk of premature labour (AOR 4.02, 95% CI 1.12-14.4, P = 0.03) and small-for-gestational-age (SGA) births (AOR 4.09, 95% CI 1.27-13.2, P = 0.02) compared with women with unrepaired VSD. CONCLUSIONS: Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text