| Popis: |
Ablative fractional lasers aim to partially remove the epidermis in a controlled manner. Two technologies represent this type of lasers, namely, erbium:yttrium-aluminum-garnet (Er:YAG, 2940 nm) and fractional carbon dioxide (CO2, 10,600 nm) lasers; both have water as target chromophore. The application of fractional photothermolysis microscopically produces zones of thermal damage that can reach even the reticular dermis, interspersed with untreated areas. This effect is called thermal micro-zones (TMZs). The efficacy of any drug therapy depends on its ability to penetrate different tissues and thus reach its target. In the skin, the stratum corneum is the main limitation for absorption of medication. TMZs allow the drug to reach deeper portions of the skin, which increases its diffusion into the tissue. There are two parameters that are variable and may be adjusted when performing drug delivery using ablative fractional lasers: density and depth of TMZs. |
