Gut-to-Brain Axis in Autism Spectrum Disorders
| Autor: | C.G.M. De Theije, Kirsten Szklany, Aletta D. Kraneveld, Johan Garssen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Psychological intervention Biology medicine.disease Bioinformatics behavioral disciplines and activities 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Gastrointestinal problems Autism spectrum disorder mental disorders Intestinal Microbiome medicine Etiology Autism Early childhood Microbiome Psychiatry 030217 neurology & neurosurgery |
| DOI: | 10.1016/bs.irn.2016.09.001 |
| Popis: | Autism spectrum disorders (ASDs) are neurodevelopmental disorders, which occur in early childhood and persist into adulthood. Although the etiology of these disorders is largely unknown, genetic and environmental factors are thought to interplay in the development of ASD. Intestinal microbial dysbiosis, in prenatal and postnatal phases, is an important example of these environmental factors, and gastrointestinal problems including adverse reactions to foods are often reported in these children. In this review, we address the clinical and preclinical findings on the role of the intestinal microbiome in ASD and suggest possible underlying mechanisms. Furthermore, opportunities for (nutritional) interventions in ASD are provided. |
| Databáze: | OpenAIRE |
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