Electron-transfer communication between redox-functionalized polymers and the active center of the enzyme glutathione reductase

Autor:	Noa Lapidot, Ron Kasher, Eran Zahavy, Itamar Willner
Rok vydání:	1992
Předmět:	Bicyclic molecule Reducing agent General Chemistry Photochemistry Biochemistry Redox Catalysis Active center Electron transfer chemistry.chemical_compound Colloid and Surface Chemistry chemistry Yield (chemistry) Conformational isomerism Methyl group
Zdroj:	Journal of the American Chemical Society. 114:10963-10965
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00053a044
Popis:	cyclohexanones-even by a relatively bulky reducing agent such as an alkoxysiliconate ion.Is The relatively greater yield of cis product from 2 compared to 1 is believed to be due, in part, to axial reduction of the small amount of the higher energy substrate conformer with the methyl group in an axial position.3a The gas-phase stereochemical results for ketones 1-3 are generally consistent with the reported behavior of these substrates toward common reducing agents in solution such as LiAIH4 and NaBH,l-! and with the predicted diastereoselectivities for reduction by LiH obtained from MO calculations” (Table I). The Occurrence of this same diastermelectivity in the gas phase implies that extrinsic factors such as speafic solvation, ion-pairing, and/or metal ion coordination effects need not necessarily be invoked, Le., that it is properly ascribed to intrinsic properties of the isolated reactants. Experiments with other cyclic, bicyclic, and acyclic ketones and ketones bearing polar substituents are in progress.
Databáze:	OpenAIRE
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