Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides

Autor:	Nilabh Chaudhary, Ganapathi R. Revankar, V. Bodepudi, T. S. Rao, J. Guy-Caffey, Krishna Jayaraman, Ross H. Durland
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Nuclease biology Chemistry Oligonucleotide General Medicine Antiparallel (biochemistry) Biochemistry Combinatorial chemistry Duplex (building) Genetics biology.protein Molecular Medicine Azole
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 14:951-955
ISSN:	1525-7770
Popis:	The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of oligonucleotides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1aae6c98b5c1716ee6d47e10f11b3b35 https://doi.org/10.1080/15257779508012509 Zobrazit plný text záznamu