COVID-19 Beyond the Lungs

Autor: Michael D. Norenberg, Halima Gamrani, Amira Zaky, Arumugam R. Jayakumar, Lahoucine Bahi, Hicham Chatoui, Faical Isbaine, Lhoussaine Ammouta, Moulay Abdelmonaim El Hidan, Nadia Zouhairi, Tiziano Balzano, Omar El Hiba
Rok vydání: 2022
Předmět:
Zdroj: Handbook of Research on Pathophysiology and Strategies for the Management of COVID-19
DOI: 10.4018/978-1-7998-8225-1.ch007
Popis: Since December 2019, the world has been shaken by the spread of a highly pathogen virus, causing severe acute respiratory syndrome (SARS-Cov2), which emerged in Wuhan, China. SARS-Cov2 is known to cause acute pneumonia: the cardinal feature of coronavirus disease 2019 (COVID-19). Clinical features of the disease include respiratory distress, loss of spontaneous breathing, and sometimes neurologic signs such as headache and nausea and anosmia, leading to suppose a possible involvement of the nervous system as a potential target of SARS-CoV2. The chapter will shed light on the recent clinical and experimental data sustaining the involvement of the nervous system in the pathophysiology of COVID-19, based on several case reports and experimental data reporting the possible transmission of SARS-CoV2 throughout the peripheral nerves to the brain cardiorespiratory centers. Thus, understanding the role of the nervous system in the course of clinical symptoms of COVID-19 is important in determining the appropriate therapeutic approach to combat the disease.
Databáze: OpenAIRE