Bendigoles A~C, New Steroids from Gordonia australis Acta 2299

Autor:	Ellen Graf, Simone Keller, Steffen Borden, Fiona M. Stainsby, Graeme J. Nicholson, Michael Goodfellow, Roderich D. Süssmuth, Hans-Peter Fiedler, Kathrin Schneider, Elisabeth Irran
Rok vydání:	2008
Předmět:	Pharmacology food.ingredient medicine.drug_class Estrogen receptor Nuclear magnetic resonance spectroscopy Biology Gordonia Molecular biology In vitro Microbiology Androgen receptor Transactivation food Mineralocorticoid Drug Discovery medicine Receptor
Zdroj:	The Journal of Antibiotics. 61:356-364
ISSN:	1881-1469 0021-8820
DOI:	10.1038/ja.2008.50
Popis:	Bendigoles A approximately C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A approximately C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.
Databáze:	OpenAIRE
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