Association between oxytocin receptor gene rs53576 polymorphism and behavioral inhibition/activation system (BIS/BAS) sensitivity
| Autor: | Shigeki Watanuki, Haruna Tsuji, Damee Choi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Oxytocin receptor Developmental psychology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Oxytocin Polymorphism (computer science) Internal medicine medicine Behavioral inhibition Allele Psychology Association (psychology) Gene 030217 neurology & neurosurgery General Psychology medicine.drug |
| Zdroj: | Personality and Individual Differences. 121:223-226 |
| ISSN: | 0191-8869 |
| Popis: | Oxytocin influences a wide range of human behaviors. Previous studies have suggested that these effects of oxytocin on human behavior are based on association with approach/withdrawal behavior. To test this hypothesis, we investigated whether the oxytocin receptor gene (OXTR) rs53576 polymorphism affects behavioral inhibition/activation system (BIS/BAS) sensitivity in healthy university students (n = 290). Our results show a significant allele-load-dependent increase by the G allele of OXTR rs53576 in BAS score, supporting previous findings that oxytocin increases approach-related behavior. Meanwhile, BIS score did not show a significant allele-load-dependent effect of OXTR rs53576, and association between oxytocin and withdrawal-related behavior is not suggested from the present study. Since the effect of OXTR rs53576 polymorphism on BAS sensitivity in the present study was relatively small, replication in a larger sample is needed to confirm this finding. |
| Databáze: | OpenAIRE |
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