A Biochemical Comparison of 6-Aminopenicillanic Acid, Benzylpenicillin, and 2,6-Dimethoxyphenylpenicillin
| Autor: | Harry G. Steinman |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
chemistry.chemical_classification
Meticillin Chromatography biology medicine.drug_class medicine.medical_treatment Antibiotics biology.organism_classification Benzylpenicillin General Biochemistry Genetics and Molecular Biology Hydrolysis Enzyme Cereus Biochemistry chemistry Beta-lactamase medicine bacteria Inducer medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 106:227-231 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-106-26295 |
| Popis: | SummaryBenzylpenicillin, 2,6-dimethoxyphenylpenicillin, and 6-aminopenicillanic acid were compared with respect to several biochemical activities. 2,6-Dimethoxy-phenylpenicillin and 6-aminopenicillanic acid were hydrolyzed at very low rates, compared to the rate for benzylpenicillin, by partially purified concentrated cell-free preparations of penicillinase derived from B. cereus, and at still lower rates by analogous preparations from S. aureus. For S. aureus, but not B. cereus, the growth-inhibitory concentrations of the two penicillinase-resistant compounds, particularly 2,6-dimethoxyphenylpenicillin, were much lower than that of benzylpenicillin. 2,6-Dimethoxyphenylpeni-cillin was a very effective inducer of penicillinase formation in B. cereus and in S. aureus. 6-Aminopenicillanic acid and benzylpenicillin were considerably less active as inducers of penicillinase in S. aureus than in B. cereus, as measured by effective inducing concentrations and by the amounts of enzyme formed. A mutant of a penici... |
| Databáze: | OpenAIRE |
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