Colorimetric Flow Injection Determination of Resorcinol-Type β2-Adrenergic Drugs with Phenanthro[9,10-d]imidazole-2-N-chloroimide

Autor:	Koji Kawanabe, Tadayasu Togawa, Shinzo Tanabe
Rok vydání:	1989
Předmět:	Flow injection analysis chemistry.chemical_compound Chromatography Chemistry Calibration curve Reagent Color reaction Imidazole Terbutaline Sulfate Resorcinol Metaproterenol Sulfate Analytical Chemistry
Zdroj:	Analytical Sciences. 5:513-516
ISSN:	1348-2246 0910-6340
Popis:	A simple and rapid flow injection method has been developed for the colorimetric determination of resorcinol-type β2-adrenergic drugs: fenoterol hydrobromide, orciprenaline sulfate and terbutaline sulfate, by using phenanthro-[9, 10-d]imidazole-2-N-chloroimide (Pl-NCl) as a color reagent. The color reaction between the drugs and Pl-NCl occurs at alkaline pH. Under the optimized conditions, the calibration curves for the three drugs were linear over the range of 0.5-200μM. The relative standard deviations (n=10) for fenoterol hydrobromide, orciprenaline sulfate and terbutaline sulfate were 1.7, 1.4 and 1.0%. The present method was applied to the determination of those drugs in commercial formulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a91fb43cea4058fe9e8226a1fe47b44 https://doi.org/10.2116/analsci.5.513 Zobrazit plný text záznamu Full text from SpringerLink