Saprotrophic bacteria as a possible means of controlling the immune status of the body through regulation of metabolic reactions

Autor: E M Mikhaĭlovskiĭ, Piruzian La
Rok vydání: 2005
Předmět:
Zdroj: Human Physiology. 31:75-85
ISSN: 1608-3164
0362-1197
DOI: 10.1007/s10747-005-0011-6
Popis: An analysis of the literature allowed a theoretical grounding of the possibility of microbial control of the immune status of the organism by the use of saprotrophic bacteria regulating its metabolic status (i.e., its enzymatic reactions). The main objective of the microbial control is protection from infections caused by conditionally pathogenic microflora. Bacterial formulations can produce the following effects: (1) a decrease in the activities of the oxidation system, glucuronyl transferase, and NAD+ glycohydrolase and an increase in the activity of glucose-6-phosphate dehydrogenase in hepatic microsomes; (2) an increase or a decrease in acetylation activity in the liver and its increase in lymphocytes; (3) an increase in the activities of the enzymes of glycolysis, the hexose monophosphate shunt, and the NADPH oxidase system, as well as succinate and glutamate dehydrogenases, acid phosphatase, α-naphthyl acetate esterase, and nonspecific esterase, in immunocompetent cells; and/or (4) stimulation of humoral and cell-mediated immunity. To achieve microbial control over the immune status of the human organism, it is necessary (1) to study the correlations between the pharmacokinetics of test substances, the activities of enzymes involved in their metabolism, and humoral and cell mediated immune reactions; (2) to determine the metabolic phenotypes of individuals; (3) to identify and systematize the normal saprotrophic microflora of each individual; (4) to elucidate the molecular mechanisms of biochemical effects exerted by saprotrophic bacteria; and (5) to select specific strains of saprotrophic bacteria that secrete substances regulating the activities of the above enzymes and metabolic processes. Different tactics of the microbial control of the individual immunity should be selected for subjects with different phenotypes.
Databáze: OpenAIRE
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