Amidation and N-Boc Deprotection Process Improvement for the Preparation of 5-(1-Piperazinyl)benzofuran-2-carboxamide, a Key Intermediate of Vilazodone

Autor:	Sony Joseph, Mohan Prasad, Hashim Nizar, Bindu Srivastava, Prasenjit Das
Rok vydání:	2014
Předmět:	chemistry.chemical_compound chemistry medicine.drug_class Organic Chemistry Vilazodone Key (cryptography) Process improvement medicine Carboxamide Physical and Theoretical Chemistry Benzofuran Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 18:665-667
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op500070t
Popis:	An improved process for the preparation of 5-(1-piperazinyl)benzofuran-2-carboxamide, a key intermediate used in the synthesis of antidepressant drug vilazodone is reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a8589eaade6cd281a2db855aa3a36dc https://doi.org/10.1021/op500070t Zobrazit plný text záznamu