Three Persistent Issues in Analysis of Clinical Trials Involving Diagnostic Contrast Agents
| Autor: | Robert Lehr, Franciska K. Kashanian |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pathology Uninterpretable business.industry Public Health Environmental and Occupational Health Contrast (statistics) Pharmacology (nursing) Analysis of clinical trials Clinical trial McNemar's test Drug Guides medicine Medical imaging Pharmacology (medical) Medical physics business |
| Zdroj: | Drug Information Journal. 43:525-532 |
| ISSN: | 2164-9200 0092-8615 |
| DOI: | 10.1177/009286150904300501 |
| Popis: | A clinical trial of the efficacy of a contrast agent used with a diagnostic procedure may present design and analysis issues that need to be considered and managed. Choice of primary variable and summary measures, multiple evaluations on each patient for the primary efficacy analysis (multiplicity), and uninterpretable or nonassessable images or regions of interest in images are three specific concerns discussed. Several methods are presented that should be considered for handling some of these issues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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