Chirality of azelastine and flezelastine: Investigation of their enantiomers

Autor:	Harald Borbe, Szelenyi I, Giancarlo Camuglia, Bernhard Kutscher, Ute Dr Achterrath-Tuckermann, Jürgen Engel, Jürgen Schmidt, Ilona Dr Fleischhauer
Rok vydání:	1993
Předmět:	Pharmacology Chemistry Stereochemistry Organic Chemistry Diastereomer Azelastine High-performance liquid chromatography Catalysis Analytical Chemistry Stereospecificity In vivo Drug Discovery medicine Organic chemistry Enantiomer Enantiomeric excess Chirality (chemistry) Spectroscopy medicine.drug
Zdroj:	Chirality. 5:366-369
ISSN:	1520-636X 0899-0042
DOI:	10.1002/chir.530050517
Popis:	The racemic phthalazinone derivatives azelastine and flezelastine were resolved via formation of diastereomeric salts and fractional crystallization thereof. The optical purity of the enantiomers was checked by HPLC. Pharmacological investigations in vitro and in vivo related to antiallergic/antiasthmatic activity revealed some stereospecific differences. However, chiral discrimination could not be observed with regard to overall activity of azelastine and flezelastine. © 1993 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a71643f120a78907d85b6dfbe90e094 https://doi.org/10.1002/chir.530050517 Zobrazit plný text záznamu Plný text