Cu(OTf)2-promoted efficient synthetic route towards glycospiro-pyrrolo[2,1-a]isoquinolines

Autor: Piyali Deb Barman, Asish Kumar Banerjee, Ishita Sanyal, Sukhendu B. Mandal
Rok vydání: 2014
Předmět:
Zdroj: Tetrahedron Letters. 55:5648-5651
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2014.08.076
Popis: A simple, convenient and efficient protocol for the construction of an array of glycospiro-pyrroloisoquinolines using isoquinolinium ylide and a carbohydrate-derived exocyclic olefin in the presence of Cu(OTf) 2 –Et 3 N catalytic system is described. Isoquinoline and alkylbromoacetates/2-bromoacetophenones were employed to generate the azomethine ylides in the presence of Et 3 N in refluxing toluene and subsequent exposure to the olefin led to the desired isoquinoline derivatives.
Databáze: OpenAIRE