Cu(OTf)2-promoted efficient synthetic route towards glycospiro-pyrrolo[2,1-a]isoquinolines
Autor: | Piyali Deb Barman, Asish Kumar Banerjee, Ishita Sanyal, Sukhendu B. Mandal |
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Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 55:5648-5651 |
ISSN: | 0040-4039 |
DOI: | 10.1016/j.tetlet.2014.08.076 |
Popis: | A simple, convenient and efficient protocol for the construction of an array of glycospiro-pyrroloisoquinolines using isoquinolinium ylide and a carbohydrate-derived exocyclic olefin in the presence of Cu(OTf) 2 –Et 3 N catalytic system is described. Isoquinoline and alkylbromoacetates/2-bromoacetophenones were employed to generate the azomethine ylides in the presence of Et 3 N in refluxing toluene and subsequent exposure to the olefin led to the desired isoquinoline derivatives. |
Databáze: | OpenAIRE |
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