Autoinflammatory Keratinization Diseases
| Autor: | A. Peña-Rosado, Jorge Romaní, N. Riera-Martí, V. Expósito-Serrano |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Histology integumentary system business.industry Acrodermatitis Dermatology Disease medicine.disease_cause medicine.disease Hidradenitis Pathology and Forensic Medicine Autoimmunity Psoriasis medicine Medical genetics Hidradenitis suppurativa Pityriasis rubra pilaris business |
| Zdroj: | Actas Dermo-Sifiliográficas (English Edition). 112:891-900 |
| ISSN: | 1578-2190 |
| DOI: | 10.1016/j.adengl.2021.09.005 |
| Popis: | Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD’s, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. The bidirectional relationship between inflammation and keratinization should be understood in order to outline optimal management, and new drug development should take both targets into account. We assume that new inflammatory keratinization diseases may be recognized as AiKDs in the coming years. |
| Databáze: | OpenAIRE |
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