Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre-eclampsia
| Autor: | Tomoko Shima, Shi-Bin Cheng, Aiko Aoki, Surendra Sharma, Tae Kusabiraki, Shigeru Saito, Akitoshi Nakashima, Osamu Yoshino |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Programmed cell death medicine.medical_specialty Obstetrics Embryogenesis Autophagy Immune regulation Obstetrics and Gynecology Placentation Biology Pathophysiology Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Placenta medicine Homeostasis |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 43:633-643 |
| ISSN: | 1341-8076 |
| Popis: | Autophagy is a well-conserved mechanism in cells from yeast to mammals, and autophagy maintains homeostasis against stress. The role of autophagy was originally shown to be a mechanism of energy production under starvation. In fact, multiple lines of evidence reveal that autophagy has numerous functions, such as protection from stress, energy regulation, immune regulation, differentiation, proliferation, and cell death. In the field of reproduction, the role of autophagy in implantation, embryogenesis, placentation, and delivery has become clearer. In addition, recent study has elucidated that the placenta has the ability to protect extraplacental cells from virus infection by activating autophagy. During resent research into autophagy, several issues have occurred in the interpretation of the autophagy status. In this review, we discuss the relation between autophagy and reproductive events, and show the importance of autophagy for placentation and pre-eclampsia. |
| Databáze: | OpenAIRE |
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