Autor: |
Tsutomu Ando, Yoshihisa Toda, Takuya Fukunaga, Chu Yiwen, Takeshi Aoki, Osamu Nozawa, Li Jun-ying, Akira Kawashima, Yuichi Terui |
Rok vydání: |
2008 |
Předmět: |
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Zdroj: |
Tetrahedron Letters. 49:3067-3070 |
ISSN: |
0040-4039 |
Popis: |
In the course of our screening program for novel glycine transporter inhibitors, we obtained a novel cyclic tetrapeptide (WSS2220) from the culture broth of Nonomuraea sp. The structure of WSS2220 was elucidated based on physicochemical data. WSS2220 contained a novel amino acid (4-oxo-3′-sulfoisoleucine), the absolute stereochemistry of which was determined by chemical modifications and the modified Mosher’s method. WSS2220 selectively inhibited glycine transporter type1 with an IC50 of 20 nM. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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