In VivoTherapeutic Effect ofVaccinium MeridionaleSwartz in Ischemia-Reperfusion Induced Male Albino Rats
| Autor: | Linyi Zheng, Mingge Shen, Ketian Li, Hongying Jing |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Necrosis Antioxidant biology medicine.medical_treatment Ischemia Glutathione 030204 cardiovascular system & hematology Pharmacology medicine.disease biology.organism_classification Lipid peroxidation Nitric oxide synthase Toxicology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Myeloperoxidase biology.protein medicine medicine.symptom Food Science Vaccinium |
| Zdroj: | Journal of Food Science. 83:221-228 |
| ISSN: | 0022-1147 |
| DOI: | 10.1111/1750-3841.13986 |
| Popis: | This study was aimed to investigate the cardioprotective and antioxidant effect of Vaccinium meridionaleSwartz in ischemia‐induced male albino Wistar strain rats. Rats were grouped into 5 of 6 numbers each. Group I served as a sham, group II served as control and group III, IV, and V served for 1, 10, and 25 mg/kg/d of an extract of Vaccinium meridionaleSwartz for 15 consecutive days of treatment. Serum marker enzymes, lipid peroxidation, and myeloperoxidase were increased, whereas antioxidant enzymes were reduced in control due to injury. Increased phenol and anthocyanin contents and increased free radical scavenging activity was noted following treatment. Serum marker enzymes, necrosis, and lipid peroxidation, were reduced, whereas antioxidant enzymes and reduced glutathione were increased. Nitric oxide synthase and Akt expression were also increased following treatment. Taking all these data together, it is suggested that Vaccinium meridionaleSwartz may be a potential therapeutic agent for the treatment of ischemic injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text