Biopharmaceutical studies of fatty suspension suppositories

Autor:	D. D. Breimer, J.J. Rutten-Kingma, C.J. de Blaey
Rok vydání:	1979
Předmět:	Pharmacology Pentobarbital Chromatography Chemistry Sodium chemistry.chemical_element Lower limit Suspension (chemistry) Bioavailability Absorption rate Biopharmaceutical medicine Pharmacology (medical) medicine.drug
Zdroj:	Pharmaceutisch weekblad. 1:1470-1473
ISSN:	1573-739X 0031-6911
DOI:	10.1007/bf02293486
Popis:	The bioavailability of pentobarbital sodium was studied in humans, as a function of the size of particles dispersed in fatty suppositories. It was found that particles of 90–100Μm exhibit a faster absorption rate compared with particles smaller than 20Μm. This confirms earlier findings on watersoluble compoundsin vitro as well asin vivo in rats. It seems therefore advisable to consider a lower limit for drug particles in suppositories for readily watersoluble compounds.
Databáze:	OpenAIRE
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