Synthesis of substituted 1,2-dihydropyridines by reaction of ethyl N-arylmalonamates with ethyl 2-(ethoxymethylidene)-3-oxobutanoate

Autor:	A. Kh. Khachatryan, S. G. Kon’kova, S. S. Hayotsyan, M. S. Sargsyan, A. E. Badasyan, A. H. Hasratyan, A. A. Sargsyan
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Ethanol chemistry 010405 organic chemistry Yield (chemistry) Organic Chemistry Michael reaction Organic chemistry 010402 general chemistry 01 natural sciences Triethylamine 0104 chemical sciences Adduct
Zdroj:	Russian Journal of Organic Chemistry. 52:857-861
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428016060166
Popis:	Michael addition of ethyl N-arylmalonamates to ethyl 2-(ethoxymethylidene)-3-oxobutanoate in ethanol in the presence of triethylamine at room temperature afforded the corresponding adducts which underwent cyclization to diethyl 1-aryl-6-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxylates in 17–65% yield. N-Alkylmalonamic acid esters failed to react with ethyl 2-(ethoxymethylidene)-3-oxobutanoate under analogous conditions.
Databáze:	OpenAIRE
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