Cryospectroscopic evidence of trimer formation between halothane and trimethylamine, stabilized by hydrogen and halogen bonds
| Autor: | Kazimierz Orzechowski, S.M. Melikova, K.S. Rutkowski, Maria Rospenk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Halogen bond Hydrogen 010405 organic chemistry Hydrogen bond Organic Chemistry Krypton chemistry.chemical_element Trimethylamine Trimer Electron donor 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Halogen Spectroscopy |
| Zdroj: | Journal of Molecular Structure. 1243:130766 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2021.130766 |
| Popis: | The reversible interaction of halothane (C2HBrClF3) with negatively charged local areas of molecular targets is defined in a large extent by the proton donor ability of C H group. This interaction leads to the formation of a hydrogen bond of the CH … B type. In the presence of heavy halogen atoms in the CHClBr group, the CX … B halogen bond can act as an alternative or additional target grip option. The results obtained by the cryospectroscopy method for solutions of halothane with large excess of trimethylamine in liquefied krypton suggest the trimer formation, stabilized by hydrogen and halogen bonds between this volatile anesthetic and electron donor targets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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