| Popis: |
The human immunodeficiency virus (HIV-1) is the aetiological agent of the acquired immune-deficiency syndrome (AIDS) (Barre-Sinoussi et al., 1983; Gallo et al., 1984). HIV-1 has the typical genetic organisation of retro viruses, with three major genes gag, pol and env. In addition, HIV-1 has additional short open reading frames that encode various regulatory proteins making it one of the most complex retroviruses that has been described (Varmus et al., 1984). The regulation of gene expression in HIV-1 has been shown to be critically dependent on the virally-encoded TAT protein (Dayton et al., 1986). |
