Preparation of N-phenyl-substituted quinolinium derivatives labeled with tritium by chemonuclear synthesis

Autor:	V. M. Fedoseev, S. B. Lewis, G.A. Alexandrova, G. A. Badun, S. E. Ukhanov, N. E. Shchepina, I. I. Boiko, V. V. Avrorin
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Reaction mechanism chemistry Nucleophile Organic Chemistry Quinoline Organic chemistry Tritium Onium Antimicrobial
Zdroj:	Chemistry of Heterocyclic Compounds. 45:796-801
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-009-0359-7
Popis:	A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a51f812f3fbedc52b0fca4f6f935c6b https://doi.org/10.1007/s10593-009-0359-7 Zobrazit plný text záznamu Plný text ve formátu PDF