Lymphangiogenesis in human dental pulp
| Autor: | Ricardo Santiago Gomez, Flávio Juliano Pimenta, Alessandra Rosa de Sá |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
CD31
Pathology medicine.medical_specialty business.industry Inflammation Stain Peripheral blood mononuclear cell Lymphangiogenesis Vascular endothelial growth factor stomatognathic diseases chemistry.chemical_compound Lymphatic system stomatognathic system chemistry Dentine caries cardiovascular system Medicine medicine.symptom business General Dentistry |
| Zdroj: | International Endodontic Journal. 36:853-856 |
| ISSN: | 0143-2885 |
| DOI: | 10.1111/j.1365-2591.2003.00728.x |
| Popis: | Aim To investigate the impact of inflammation on lymphangiogenesis in human dental pulp. Methodology Eleven samples of dental pulp without inflammation and 11 dental pulps with moderate to intense mononuclear cell inflammatory infiltrate associated with dentine caries were selected. The streptavidin–biotin complex stain was used to detect CD31, vascular endothelial growth factor receptor-3 (VEGFR-3) and α-smooth muscle actin. The number of lymphatic vessels was obtained by counting the number of vessels positive for CD31 and VEGFR-3 and negative for α-smooth muscle actin. Results The results demonstrated that the mean number (±SD) of vessels positive for CD31 and VEGFR-3 (lymphatic vessels) in the group with inflammation (6.09 ± 1.81) was statistically higher (P = 0.0123) than the mean number in the group without inflammation (3.73 ± 2.20). Conclusion Increased co-immunostaining of CD31 and VEGF-3 in vessels associated with human dental pulp inflammation occurred, which suggests lymphangiogenesis. |
| Databáze: | OpenAIRE |
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