| Autor: |
Liu-Meng Yang, Wei-Lie Xiao, Yanqiong Shen, Han-Dong Sun, Qiu-Fen Hu, Liying Yang, Yun-Qi Li, Zheng Yong-Tang, Li-Dan Shu, Xue-Mei Gao |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Bulletin of the Korean Chemical Society. 34:827-830 |
| ISSN: |
0253-2964 |
| DOI: |
10.5012/bkcs.2013.34.3.827 |
| Popis: |
Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
