MORTALITY FROM CORONARY HEART DISEASE IN THE TECUMSEH STUDY
| Autor: | Donald E. Lamphiear, William J. Butler, Wendy J. Carman, Leon D. Ostrander |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Glucose tolerance test medicine.diagnostic_test Epidemiology business.industry Cholesterol Population medicine.disease chemistry.chemical_compound Endocrinology Blood pressure chemistry Internal medicine Diabetes mellitus Cohort medicine Analysis of variance Risk factor education business |
| Zdroj: | American Journal of Epidemiology. 121:541-547 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/oxfordjournals.aje.a114031 |
| Popis: | The coronary heart disease mortality of participants in the Tecumseh study was examined with particular emphasis on the roles of diabetes and glucose tolerance as risk factors. The cohort consisted of 921 men and 937 women aged 40 years and older who did not have evident coronary heart disease at entry to the study during the period 1959-1965 and whose outcome was determined in the period 1977-1979. Previously diagnosed diabetes was a statistically significant risk factor for coronary heart disease mortality in both sexes even after controlling for systolic blood pressure, serum cholesterol, relative weight, and cigarette smoking. High blood glucose score in nondiabetics was associated with excess coronary heart disease mortality after controlling for other risk factors, but the magnitude of this effect was substantially below that of diabetes. The predictive power of most risk factors except age itself decreased among progressively older segments of the population. |
| Databáze: | OpenAIRE |
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