Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study
| Autor: | Jennifer S. Ford, Charles A. Sklar, David H. Abramson, Yuelin Li, Kevin C. Oeffinger, Danielle Novetsky Friedman, Joanne F. Chou, Mary S. McCabe, Ira J. Dunkel, Leslie L. Robison, Ruth A. Kleinerman, Brian P. Marr |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pediatrics Chronic condition business.industry Absolute risk reduction Retrospective cohort study Common Terminology Criteria for Adverse Events Childhood Cancer Survivor Study humanities Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Relative risk Cohort 030221 ophthalmology & optometry medicine business |
| Zdroj: | Cancer. 122:773-781 |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND Limited data are available regarding long-term morbidity in adult survivors of retinoblastoma (Rb). METHODS The Retinoblastoma Survivor Study is a retrospective cohort of adult survivors of Rb diagnosed between 1932 and 1994. Participants completed a comprehensive questionnaire adapted from the Childhood Cancer Survivor Study surveys. Chronic conditions were classified using the National Cancer Institute's Common Terminology Criteria for Adverse Events (version 4.03). Multivariate Poisson regression was used to compare survivors of Rb with 2377 non-Rb controls, consisting of the Childhood Cancer Survivor Study sibling cohort and survivors with bilateral versus unilateral disease. RESULTS Survivors of Rb (53.6% with bilateral disease) and non-Rb controls had a mean age of 43.3 years (standard deviation, 11 years) and 37.6 years (SD, 8.6 years), respectively, at the time of study enrollment. At a median follow-up of 42 years (range, 15-75 years), 86.6% of survivors of Rb had at least 1 condition and 71.1% had a severe/life-threatening (grade 3-4) condition. The adjusted relative risk (RR) of a chronic condition in survivors compared with non-Rb controls was 1.4 (95% confidence interval [95% CI], 1.3-1.4; P |
| Databáze: | OpenAIRE |
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