| Autor: |
Alka Khera, Jagat Ram, Madhu Khullar, Faisal Thattaruthody, Parul Chawla Gupta, Gaurav Kumar, Nirbhai Singh, Surinder Singh Pandav |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2149707/v1 |
| Popis: |
Pseudoexfoliation syndrome (XFS) effects the intraocular pressure (IOP) and vision of eye by causing pseudoexfoliation glaucoma (XFG). miRNAs have previously been linked to the aetiology of XFS and XFG. Present study focuses on the differential expression pattern of microRNAs (miRNAs) in anterior lens capsule (ALC) of XFS and XFG. For this, RNA from ALC of XFS, XFG and control patients was subjected to miRNA array followed by validation of clinically important significantly expressed miRNAs and their targets by real-time PCR. Out of 44 differentially expressed miRNAs, miR-638 showed significant increase in expression in XFG samples as compared to XFS and control (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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