123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study
| Autor: | Junji Komatsu, Takahiko Tokuda, Kenji Wada, Mitsuhiro Yoshita, Tetsuaki Arai, Hiroyuki Arai, Yoshikuni Mizuno, Hirotaka Maruno, Junichi Taki, Takashi Asada, Kenji Kosaka, Akira Takahashi, Kenji Nakashima, Kenichi Nakajima, Seigo Nakano, Katsuya Urakami, Kenichi Kashihara, Satoshi Orimo, Etsuro Mori, Yukihiko Washimi, Hiroyuki Nakamura, Heii Arai, Eizo Iseki, Junichi Yamasaki, Katsuyoshi Mizukami, Yoshiyuki Nishio, Hiroshige Fujishiro, Osamu Iizuka, Haruo Hanyu, Masahito Yamada, Kumiko Utsumi, Miharu Samuraki, Shouhei Yamashina |
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| Rok vydání: | 2018 |
| Předmět: |
Receiver operating characteristic
medicine.diagnostic_test business.industry Dementia with Lewy bodies Cross-sectional study Scintigraphy medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Myocardial scintigraphy Medicine Surgery Neurology (clinical) Medical diagnosis Stage (cooking) business Nuclear medicine 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 89:1167-1173 |
| ISSN: | 1468-330X 0022-3050 |
| Popis: | Background and purposeWe previously reported the usefulness of iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy for differentiation of dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) in a cross-sectional multicentre study. The aim of this study was, by using reassessed diagnosis after 3-year follow-up, to evaluate the diagnostic accuracy of 123I-MIBG scintigraphy in differentiation of probable DLB from probable AD.MethodsWe undertook 3-year follow-up of 133 patients with probable or possible DLB or probable AD who had undergone 123I-MIBG myocardial scintigraphy at baseline. An independent consensus panel made final diagnosis at 3-year follow-up. Based on the final diagnosis, we re-evaluated the diagnostic accuracy of 123I-MIBG scintigraphy performed at baseline.ResultsSixty-five patients completed 3-year follow-up assessment. The final diagnoses were probable DLB (n=30), possible DLB (n=3) and probably AD (n=31), and depression (n=1). With a receiver operating characteristic curve analysis of heart-to-mediastinum (H/M) ratios for differentiating probable DLB from probable AD, the sensitivity/specificity were 0.77/0.94 for early images using 2.51 as the threshold of early H/M ratio, and 0.77/0.97 for delayed images using 2.20 as the threshold of delayed H/M ratio. Five of six patients who were diagnosed with possible DLB at baseline and with probable DLB at follow-up had low H/M ratio at baseline.ConclusionsOur follow-up study confirmed high correlation between abnormal cardiac sympathetic activity evaluated with 123I-MIBG myocardial scintigraphy at baseline and the clinical diagnosis of probable DLB at 3-year follow-up. Its diagnostic usefulness in early stage of DLB was suggested.Trial registration numberUMIN00003419. |
| Databáze: | OpenAIRE |
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