Immunologic tolerance and immunity to tuberculosis

Autor:	M. M. Averbakh, V. I. Litvinov, I. N. Il'ina, Markov An
Rok vydání:	1980
Předmět:	Cellular immunity Tuberculosis Cyclophosphamide business.industry Tuberculin General Medicine Disease medicine.disease Virology General Biochemistry Genetics and Molecular Biology Vaccination Immunity Immunology medicine business Immunologic Tolerance medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 89:180-182
ISSN:	1573-8221 0007-4888
Popis:	The intensity of immunity to tuberculosis and resistance to the disease in the case of infection with the virulent strainMycobacterium tuberculosis H37Rv were studied in a model of immunologic tolerance induced in CBA mice by injection of a large dose of BCG polyantigen and the immunodepressant cyclophosphamide. Cellular immunity to tuberculosis (tested by the blasttransformation and tuberculin skin tests) was shown not to develop in tolerant animals after BCG vaccination, and vaccination had no protective effect under these circumstances in the group of tolerant mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a1ed54f7ab969818dbadf4bf24199d0 https://doi.org/10.1007/bf00831016 Zobrazit plný text záznamu Full text from SpringerLink