ORIGINAL ARTICLE: The Effect of Oxidative Environment on Immunosuppressive Properties of Human Seminal Plasma
| Autor: | Marta Antich, J.R. Palacio, Paz Martínez, Roger Badia, A. Iborra |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Thiobarbituric acid medicine.medical_treatment Immunology Obstetrics and Gynecology Semen Immunosuppression Lymphocyte proliferation Biology medicine.disease_cause Malondialdehyde Sperm In vitro chemistry.chemical_compound Endocrinology Reproductive Medicine chemistry Internal medicine medicine Immunology and Allergy Oxidative stress |
| Zdroj: | American Journal of Reproductive Immunology. 60:354-360 |
| ISSN: | 1046-7408 |
| Popis: | Problem Human seminal plasma (SP) has an important immunosuppressive function that enables sperm survival in the female reproductive tract. The aim of this study was to evaluate how oxidized proteins, by oxidative stress, may influence seminal plasma immunosuppressive properties in male infertility. Method of study Human SP immunosuppressive ability was evaluated by a lymphocyte proliferation assay. We used phytohemagglutinin mitogen to induce lymphocyte proliferation in the presence of human SP from infertile and fertile men, and under in vitro oxidizing conditions. Human SP-oxidized proteins (MDA-protein) were determined by the thiobarbituric acid test. Results Significant high levels of oxidized proteins were found in SP from asthenozoospermic patients. There was a significant difference (P |
| Databáze: | OpenAIRE |
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