| Autor: |
H. Chams, Yoshihiko Katsuyama, Masao Ota, K. Funakoshi, Nobuhisa Mizuki, Abbas Ghaderi, Behrooz Nikbin, Hidetoshi Inoko, Eiichi Nomura, H. Ando, Fereydoun Davatchi, Kazuro Yabuki, Shigeaki Ohno |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Tissue Antigens. 60:396-399 |
| ISSN: |
0001-2815 |
| DOI: |
10.1034/j.1399-0039.2002.600506.x |
| Popis: |
We have previously suggested that in a Japanese population the susceptible locus for Behcet's disease (BD) is HLA-B51 itself. To confirm this finding in another population, we performed HLA class I typing using the PCR-SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA-B gene using automated sequencer and subsequent automated fragment detection by fluorescent-based technology with the DNA samples of 84 Iranian patients with BD and 87 healthy ethnically matched controls. As a result, three microsatellite alleles (MICA-A6, MIB-348, C1-4-1-217) and HLA-B51 were found to be strongly associated with BD. Of these alleles HLA-B51 is the most strongly associated allele. There were no alleles that were increased in allele frequency at any microsatellite loci centromeric of MICA or telomeric of HLA-B51. Therefore, HLA-B51 was confirmed to be by far the most strongly associated gene with BD in an Iranian population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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