Guanine-Containing DNA Minor-Groove Binders

Autor:	Anna Grandas, Albert Sánchez, Daniel Pulido, Enrique Pedroso, Jordi Robles
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Stereochemistry Oligonucleotide Ligand Guanine C-terminus Organic Chemistry Lysine chemistry.chemical_compound Molecular recognition chemistry polycyclic compounds Nucleotide Physical and Theoretical Chemistry DNA
Zdroj:	European Journal of Organic Chemistry. 2009:1398-1406
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200800892
Popis:	Solid-phase procedures have been used to prepare six dipyrrole-containing DNA ligands that combine (guanin-9-yl)acetyl, (guanin-7-yl)acetyl or acetyl moieties at the N-terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA-stabilizing properties by UV-monitored thermal denaturation experiments showed that the ligand incorporating the (guanin-9-yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex-stabilizing effects.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Databáze:	OpenAIRE
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