The Combined use of Calcitonin Doubling time and 18F-FDG PET/CT Improves Prognostic Values in Medullary Thyroid Carcinoma: the Clinical Utility of 18F-FDG PET/CT
| Autor: | Cleber P. Camacho, Lilian Yuri Itaya Yamaga, Ji H. Yang, Jairo Wagner, Flávia O. F. Valente, Susan C. Lindsey, Rui M. B. Maciel, Danielle M. Andreoni, Rosa Paula M. Biscolla |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Endocrinology Diabetes and Metabolism Medullary thyroid cancer 030209 endocrinology & metabolism Standardized uptake value medicine.disease Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Endocrinology Carcinoembryonic antigen Positron emission tomography Calcitonin 030220 oncology & carcinogenesis medicine biology.protein Doubling time Radiology business Nuclear medicine Progressive disease |
| Zdroj: | Endocrine Practice. 23:942-948 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep171806.or |
| Popis: | Objective: Calcitonin and carcinoembryonic antigen (CEA) doubling times are established prognostic markers in medullary thyroid cancer (MTC). On the other hand, 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) shows an increased rate of detection with high blood tumor marker levels in several cancers. This study aimed to analyze the ability of 18F-FDG PET/CT to determine prognosis in the follow-up of patients with MTC. Methods: Medical records of 17 patients with MTC who underwent 18F-FDG PET/CT were analyzed retrospectively. All patients were classified into two groups: stable disease or progressive disease. Results: Eight patients presented with progressive disease, and all of them showed 18F-FDG uptake (100%), compared to only 3 of 9 patients who presented in stable condition (33%). 18F-FDG PET/CT results were able to distinguish progressive from stable disease (P = .009). Calcitonin levels >4,020 pg/mL (P = .0004), CEA levels >26.8 ng/mL (P = .04), and a calcitonin doubling time Conclusion:18F-FDG uptake was able to distinguish progressive from stable disease. However, this tool should not replace the validated calcitonin doubling time, but rather the combination of information could improve the clinical re-assessment and better identify high-risk patients who require more careful surveillance. Abbreviations: CEA = carcinoembryonic antigen CT = computed tomography 18F-FDG = 18F-fluorodeoxyglucose MTC = medullary thyroid cancer PET = positron emission tomography PVE = proportion of variance explained sCT = serum calcitonin SUV = standard uptake value US = ultrasound |
| Databáze: | OpenAIRE |
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