| Autor: |
Ádria Aline Alves Monteiro, Simone Rodrigues dos Passos, Gabriela Nascimento de Lemos, Nivin Mazen Said, João Soares Felício, Pedro Paulo Freire Piani, Natércia Neves Marques de Queiroz, Franciane Trindade Cunha de Melo, Ana Carolina Contente Braga de Souza, Lorena Vilhena de Moraes, Karem Miléo Felício, Maria Clara Neres Iunes de Oliveira, Danielle Dias da Silva Pinheiro, Ícaro José Araújo de Souza, Emanuele Rocha da Silva, João Felício Abrahão Neto, Wanderson Maia da Silva, Neyla Arroyo Lara Mourão, Isabel Jane Campos Lobato, Lilian de Souza D’Albuquerque Silva, Angélica Leite de Alcântara |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-710569/v1 |
| Popis: |
Background: Type 1 Diabetes Mellitus (T1DM) impacts health-related quality of life (HRQoL). Cross-sectional studies suggest that low levels of vitamin D (VD) may impair HRQoL, however, the effect of VD supplementation on quality of life in patients with T1DM has not yet been clarified. The objective of the study was to evaluate the effects of high-dose VD supplementation on HRQoL in patients with T1DM. Methods: We performed a prospective interventional study with 64 patients supplemented with high doses of cholecalciferol (4,000 IU/day for patients with 25-OH-vitamin D [25(OH)D] between 30 and 60 ng/mL, and 10,000 IU/day for those with 25(OH)D below 30 ng/mL) for 12 weeks. HRQoL was assessed with EuroQol instruments (EQ-5D and EQ-VAS). Results: There was an improvement in global EQ-5D index at the end of vitamin D supplementation. Analysing only the EQ-5D domains, we observed particularly an improvement in mobility (1.3 ± 0.6 versus 1.1 ± 0.3, p Conclusion: Our data showed that high doses of cholecalciferol supplementation can improve HRQoL in patients with T1DM, and the reduction of albuminuria seems to be an important factor in this context.Trial registration: ISRCTN, ISRCTN32601947. Registered 3 June 2017 - Retrospectively registered, http://www.isrctn.com/ISRCTN32601947 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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