Effects of Various Timings and Concentrations of Inhaled Nitric Oxide in Lung Ischemia–Reperfusion
| Autor: | Philippe Dartevelle, Philippe Hervé, Guy Michel Mazmanian, Hélène Détruit, Alain Chapelier, Shinya Murakami, Emile A. Bacha |
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| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung business.industry Myeloperoxidase activity Ischemia Pharmacology Lung injury Critical Care and Intensive Care Medicine medicine.disease Nitric oxide chemistry.chemical_compound medicine.anatomical_structure chemistry Anesthesia Lung ischemia medicine Vascular resistance Lung tissue business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 156:454-458 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.156.2.9608007 |
| Popis: | Experimental studies reveal that inhaled nitric oxide (NO) can prevent, worsen, or have no effect on lung injury in the setting of ischemia–reperfusion (I–R). We tested the hypothesis that these disparate effects could be related to differences in the timing of administration and/or concentration of inhaled NO during I–R. Isolated rat lungs were subjected to 1-h periods of ischemia followed by 1-h periods of blood reperfusion. We investigated the effects of NO (30 ppm) given during ischemia, NO (30 or 80 ppm) begun immediately at reperfusion, or NO (30 ppm) given 15 min after the beginning of reperfusion, on total pulmonary vascular resistance (PVR), the coefficient of filtration (Kfc), the lung wet/dry weight ratio (W/D) of lung tissue, and lung myeloperoxidase activity (MPO). A control group did not receive NO. NO given during ischemia had no effect on Kfc or MPO, but decreased PVR. NO (30 ppm) during reperfusion (early or delayed) decreased PVR, W/D, Kfc, and MPO. NO at 80 ppm decreased PVR and MPO but... |
| Databáze: | OpenAIRE |
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