RhoGDIα downregulates androgen receptor signaling in prostate cancer cells

Autor:	Wei Lou, Nagalakshmi Nadiminty, Ramakumar Tummala, Chengfei Liu, Allen C. Gao, Yezi Zhu
Rok vydání:	2013
Předmět:	medicine.medical_specialty Urology Transfection Biology medicine.disease law.invention Androgen receptor Prostate cancer Endocrinology Oncology Downregulation and upregulation law Internal medicine RHO GDP-DISSOCIATION INHIBITOR ALPHA Cancer research medicine Suppressor Signal transduction
Zdroj:	The Prostate. 73:1614-1622
ISSN:	0270-4137
DOI:	10.1002/pros.22615
Popis:	INTRODUCTION Treatment of primary prostate cancer (CaP) is the withdrawal of androgens. However, CaP eventually progresses to grow in a castration-resistant state due to aberrant activation of androgen receptor (AR). Understanding the mechanisms leading to the aberrant activation of AR is critical to develop effective therapy. We have previously identified Rho GDP Dissociation Inhibitor alpha (GDIα) as a novel suppressor in prostate cancer. In this study, we examine the effect of GDIα on AR signaling in prostate cancer cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::19f9e16e91d125cd78b33a720e677f7f https://doi.org/10.1002/pros.22615 Zobrazit plný text záznamu Plný text