Differential expression of β2-integrins and cytokine production between γδ and αβ T cells in experimental autoimmune encephalomyelitis
| Autor: | Scott R. Barnum, Sherry S. Smith |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cell adhesion molecule
medicine.medical_treatment Immunology Experimental autoimmune encephalomyelitis chemical and pharmacologic phenomena hemic and immune systems Spleen Cell Biology Biology medicine.disease stomatognathic diseases Cytokine medicine.anatomical_structure Neuroimmunology medicine Demyelinating disease Immunology and Allergy Interferon gamma Tumor necrosis factor alpha medicine.drug |
| Zdroj: | Journal of Leukocyte Biology. 83:71-79 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0407263 |
| Popis: | The expression of beta 2-integrins on gammadelta T cells in naive mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlike in alphabeta T cells, beta 2-integrin expression on gammadelta T cells increased significantly from baseline, peaked at Day 10, and remained unchanged in the draining lymph nodes or declined in the spleen and CNS by Day 15. In addition, IFN-gamma- and TNF-alpha-producing gammadelta T cells infiltrated the CNS rapidly and produced significantly more of these cytokines than alphabeta T cells throughout the course of EAE. These results suggest unique roles for beta 2-integrins in the trafficking of gammadelta versus alphabeta T cells during EAE and that gammadelta T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease. |
| Databáze: | OpenAIRE |
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