Function of flavins in photolysis of bilirubin in vitro

Autor:	Jiří Herzman, Roman Hodr, Věra Houdková, Eduard Knobloch
Rok vydání:	1982
Předmět:	chemistry.chemical_compound chemistry Bilirubin digestive oral and skin physiology Photodissociation food and beverages heterocyclic compounds General Chemistry Flavin group Photochemistry human activities In vitro Function (biology)
Zdroj:	Collection of Czechoslovak Chemical Communications. 47:1514-1522
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc19821514
Popis:	In the course of photochemical oxidation of bilirubin, riboflavin works as a reversible electron acceptor undergoing a transformation into the riboflavin-leucoform. Simultaneously bilirubin is irreversibly decomposed. Under anaerobic conditions the bilirubin-riboflavin system behaves as an electrochemical equilibrium system, characterized by its redox potential. Leucoform formation was detected by spectrophotometry, polarography and potentiometry. Under aerobic conditions the expected photochemical equilibrium is not established probably owing to the reoxidation of riboflavin-leucoform by oxygen. Of the flavin derivatives present in blood riboflavin, FAD and FMN were tested, riboflavin being the most effective one. This paper summarizes the model studies of biochemical function of flavins, which could be applied to the phototherapy of neonatal jaundice.
Databáze:	OpenAIRE
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