Nitric oxide modulates and adenosine mediates the tubuloglomerular feedback mechanism
| Autor: | Russell D. Brown, Anna Ollerstam, Ruisheng Liu, A. E. G. Persson |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Kidney urogenital system Physiology Chemistry Juxtaglomerular apparatus Adenosine Nitric oxide Adenosine A1 receptor chemistry.chemical_compound medicine.anatomical_structure Endocrinology Internal medicine Renin–angiotensin system medicine Macula densa Tubuloglomerular feedback medicine.drug |
| Zdroj: | Acta Physiologica Scandinavica. 176:91-94 |
| ISSN: | 0001-6772 |
| DOI: | 10.1046/j.1365-201x.2002.01026.x |
| Popis: | The tubuloglomerular feedback (TGF) mechanism is an important regulator of the glomerular filtration rate (GFR) and urine excretion rate. It operates by sensing the distal delivery of fluid at the macula densa site and adjusting the tone of the glomerular arterioles to control GFR. We found evidence that nitric oxide is an important modulator of the setting of the sensitivity of the TGF mechanism. Studies on adenosine A1 receptor deficient mice have shown that these animals lack the TGF response and have an increased renin release. These findings show the important role of adenosine as a mediator of the signal for the TGF mechanism and as an inhibitor of renin release. |
| Databáze: | OpenAIRE |
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