Nanostructural Mechanism of Modifying Adaptation of Proteoglycan Systems of Biological Tissues and Mucus

Autor:	N. F. Lanina, A. V. Zabelin, A.A. Vazina, G. S. Marinsky, A. A. Vasilieva, M. S. Kvasha, V. N. Korneev, G. N. Kulipanov, S. E. Podpryatov, Barry E. Paton, S. S. Podpriatov, V. M. Shelestov, S. G. Gichka, V. D. Vasiliev, V. A. Vasilchenko
Rok vydání:	2018
Předmět:	010302 applied physics chemistry.chemical_classification Structural organization biology 010308 nuclear & particles physics Chemistry chemistry.chemical_element General Chemistry Polymer Calcium Condensed Matter Physics 01 natural sciences Mucus Extracellular matrix Proteoglycan 0103 physical sciences biology.protein Biophysics General Materials Science
Zdroj:	Crystallography Reports. 63:1063-1070
ISSN:	1562-689X 1063-7745
DOI:	10.1134/s1063774518070258
Popis:	Results of longitudinal X-ray diffraction studies of the structural organization of biological tissues from humans and animals in different physiological states using Russian sources of synchrotron radiation from the VEPP-3 and Siberia-2 storage rings are presented. The X-ray diffraction patterns of mucus and epithelial tissues show many orders of Debye rings at the main spacing of 4.65 (±0.15) nm, which was attributed to proteoglycan systems of the extracellular matrix of different tissues. The periodicity was experimentally shown to be invariable at a nanoscale level in a broad evolutionary framework. The nanostructural transformation of proteoglycan systems was found to be induced by the synergistic effect of high-frequency electrosurgical welding, which is widely used in clinical surgery. Through the lens of statistical physics of polymer networks, proteoglycans can be considered as labile systems capable of modifying adaptation through the formation of reversible chelate complexes with calcium cations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::19cb7926d67cb0ba44134237f55eed20 https://doi.org/10.1134/s1063774518070258 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.