Chemo- and Stereoselective Reduction of β-Keto-α-oximino Nitriles by Using Baker's Yeast

Autor:	Jae Wook Lee, Yong Sup Lee, Soon Bang Kang, Youseung Kim, Gyochang Keum, Kilwoong Mo
Rok vydání:	2014
Předmět:	NMR spectra database Chemistry Lower yield Organic Chemistry Organic chemistry Stereoselectivity Physical and Theoretical Chemistry Enantiomer Chemoselectivity Enantiomeric excess Yeast
Zdroj:	European Journal of Organic Chemistry. 2015:1137-1143
ISSN:	1434-193X
DOI:	10.1002/ejoc.201403393
Popis:	The baker’s yeast mediated reduction of β-keto-α-oximino nitriles 3 at 20 °C gave β-hydroxy-α-oximino nitriles 4 in high yields with high enantiomeric purity [enantiomeric excess (ee) values 99%]. At room temperature, the same reaction afforded the product in a slightly lower yield. The β-hydroxyα-oximino nitriles 4 were obtained as single stereoisomers according to chiral GC–MS analyses and the 1 H and 19 F NMR spectra of the corresponding Mosher esters. The abso
Databáze:	OpenAIRE
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