Preparation and characterization of wet-milled cyclovirobuxine D nanosuspensions

Autor: Xiangshuai Gu, Wannian Zhang, Tianyan Han, Jianhong Yang, Jinjiao Yong, Qiang Liu
Rok vydání: 2019
Předmět:
Zdroj: Journal of Thermal Analysis and Calorimetry. 139:1959-1970
ISSN: 1588-2926
1388-6150
Popis: This study aims to develop nanosuspensions for improving the dissolution of poorly water-soluble cyclovirobuxine D (CVB-D) containing a binary stabilizer system and further characterize the stabilization potential and physical–chemical variables of CVB-D nanosuspensions. Binary stabilizers of croscarmellose sodium (CCS) with hydroxypropyl methyl cellulose acetate succinate (HPMCAS), hydroxypropyl β cyclodextrin (H-β-CD) and cross-linked polyvinylpyrrolidone (CP) were chosen for nanosuspensions. The rapid dissolution of CVB-D nanosuspensions was achieved by wet media milling. By observing the stability after 30 days of storage, the combination of CCS with HPMCAS was determined to be the most effective binary system. The relative order of effectiveness of the combinations was as follows: CCS/HPMCAS > CCS/CP > CCS/H-β-CD. The obtained particle size and polydispersity index were both within an acceptable range. The particle surface morphology, miscibility, thermal stability and molecular binding energy of CVB-D nanosuspensions were subsequently characterized by SEM, FTIR, TG-DSC and NMR spectroscopy. The results revealed that smaller particle size and better miscibility have a significant contribution to the dissolution and stability of CVB-D nanosuspensions. Overall, these promising results open new perspectives for improving the stability and dissolution rate for CVB-D and other alkaloids.
Databáze: OpenAIRE
Externí odkaz: