Kinetics of Spontaneous Conversion of Methylcobalamin into Hydroxocobalamin in Aqueous and Methanol Solutions HPLC/MS

Autor:	Stanislav V. Yefimov
Rok vydání:	2022
Předmět:	General Medicine
Zdroj:	Scholars Academic Journal of Pharmacy. 11:176-181
ISSN:	2320-4206 2347-9531
DOI:	10.36347/sajp.2022.v11i10.001
Popis:	This work aimed to determine the stability of methylcobalamin in injection solutions under light-protected conditions, identify the products of its spontaneous transformation, and determine the kinetics of these transformations. We have found that methylcobalamin is unstable and transforms into hydroxocobalamin spontaneously at room temperature in aqueous and methanol solutions protected from light. Kinetics, reaction products, and rate constants have been determined. A method for the qualitative and quantitative determination of methylcobalamin and its conversion products is proposed.
Databáze:	OpenAIRE
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