Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome
| Autor: | Isabel Marugán, Maria Dolores Bea, Jose A. Rodriguez, Antonio Ferrández, María José Terol, Isabel Benet, Mar Tormo, Antonio Gutierrez, Carlos Solano |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Hemophagocytic lymphohistiocytosis business.industry Hypereosinophilic syndrome Interleukin Hypereosinophilia Hematology General Medicine medicine.disease Peripheral T-cell lymphoma Lymphoma medicine.anatomical_structure Immunology medicine Bone marrow medicine.symptom business CD8 |
| Zdroj: | European Journal of Haematology. 71:303-306 |
| ISSN: | 0902-4441 |
| DOI: | 10.1034/j.1600-0609.2003.00051.x |
| Popis: | Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T-cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)-5 was found. Interestingly, progression of the lymphoma coincided with an increase in the serum levels of several Th2 cytokines and IL-2, a decrease in tumor necrosis factor and granulocyte-macrophage colony-stimulating factor levels and the onset of a hypereosinophilic syndrome. |
| Databáze: | OpenAIRE |
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